منابع مشابه
The neuroimmune-neuroplasticity interface and brain pathology
It is now well-established that the brain, although immune privileged, has fundamental interactions with elements of the immune system. Perhaps, one of the most exciting aspects of such neuroimmune communication, has been the notion that peripheral derived immune factors (e.g., lymphocytes and cytokines), as well as central glia (particularly microglia) are thought to participate in the modulat...
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Microglia is one of the first innate immune components. These cells account about 5 to 10% of the entire adult brain cells and are activated by trauma. Complex-mediated inflammatory responses occur through cellular and molecular events during and after the traumatic brain injury (TBI). In-lesion area astrocytes, microglia, and damaged neurons begin to secrete cytokines and chemokines. Microglia...
متن کاملNeuroinflammation and Neuroimmune Dysregulation after Acute Hypoxic-Ischemic Injury of Developing Brain
Hypoxic-ischemic (HI) injury to developing brain results from birth asphyxia in neonates and from cardiac arrest in infants and children. It is associated with varying degrees of neurologic sequelae, depending upon the severity and length of HI. Global HI triggers a series of cellular and biochemical pathways that lead to neuronal injury. One of the key cellular pathways of neuronal injury is i...
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ژورنال
عنوان ژورنال: Trends in Immunology
سال: 2021
ISSN: 1471-4906
DOI: 10.1016/j.it.2021.04.003